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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Tpr-met fusion protein ： ウィキペディア英語版 Tpr-met fusion protein == Structure == Tpr-Met fusion protein is an oncogene fusion protein consisting of TPR and MET. Tpr-Met was generated following a chromosomal rearrangement induced by the treatment of a human osteogenic sarcoma cell line with the carcinogen ''N''-methyl-''N'''-nitronitrosoguanidine. The genomic rearrangement fuses two genetic loci,''translocated promoter region'', from chromosome 1q25 which encodes a dimerization leucine zipper motif, and ''MET'', from chromosome 7q31 which contributes the kinase domain and carboxy-terminus of the Met RTK. The resulting 65 kDa cytoplasmic Tpr-Met oncoprotein forms a dimer mediated through the Tpr leucine zipper. The Tpr-Met fusion protein lacks the extracellular, transmembrane and juxtamembrane domains of c-Met receptor, and has gained the Tpr dimerization motif, which allows constitutive and ligand-independent activation of the kinase. The loss of juxtamembrane sequences, necessary for the negative regulation of kinase activity and receptor degradation, prolongs duration of Met signalling. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tpr-met fusion protein」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.